Ryan Knake , PA-C
Physician Assistant • Cape Coral, FL
2721 Del Prado Blvd S Ste 230b
Cape Coral, FL 339045993
This profile restates public CMS/NPPES data; T-MedInfo gives no medical advice — consult a licensed professional, and call 911 for emergencies.
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NPI assigned on March 5, 2015; this date does not establish years in practice.
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Published CMS data list 1,680 Original Medicare Part B services in 2024.
Source: CMS, Medicare Physician & Other Practitioners – by Provider and Service, 2024. Published rows only; this is not a quality measure.
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Published Part B service records, 2024:
- 99231 — Subsequent hospital care with straightforward or low level of medical decision making, per day: 1,296 service units.
- 99232 — Subsequent hospital care with moderate levelof medical decision making: 307 service units.
- 99222 — Initial hospital care with straightforward or low-level medical decision making: 39 service units.
Source: CMS, Medicare Physician & Other Practitioners – by Provider and Service, 2024. Units differ by code; these are not visits or a measure of quality.
CPT® only copyright 2023 American Medical Association. All rights reserved. Service names are shortened from CPT Consumer Friendly Descriptors (CMS data, 2024). CPT notice
See all 4 records in the table · Guide: How to read Medicare Part B data
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Published CMS data list 211 Medicare Part D prescriptions, including refills, in 2024.
Source: CMS, Medicare Part D Prescribers – by Provider and Drug, 2024. Published rows only; this is not a quality measure.
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Published Part D records, 2024:
- Tamsulosin Hcl — 57 prescription fills, including refills.
- Prednisone — 36 prescription fills, including refills.
- Abiraterone Acetate — 29 prescription fills, including refills.
Source: CMS, Medicare Part D Prescribers – by Provider and Drug, 2024. Drug names come from pharmacy claims. Listing a drug here is not an endorsement or a recommendation.
See all 8 records in the table · Guide: How to read Medicare Part D prescriber data
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More Medicare Part B services than 65% of clinicians listed under Physician Assistant in Cape Coral, FL (2024, 40 clinicians with data). Median for this group: 368. Middle half: 77 to 2,033.
More Medicare Part B services than 85% of clinicians listed under Physician Assistant in Florida (2024, 4,397 clinicians with data). Median for this group: 252. Middle half: 82 to 807.
Source: CMS, Medicare Physician & Other Practitioners – by Provider and Service, 2024. Billing and prescribing volume is not a quality rating.
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Medicare Part B services went from 142 in 2020 to 1,680 in 2024.
Source: CMS, Medicare Physician & Other Practitioners – by Provider and Service, 2020–2024.
Practice Location & Contact Primary Location
2721 Del Prado Blvd S Ste 230b
Cape Coral, FL 339045993
Matched by practice address or phone in NPPES. A shared address or phone does not confirm that this clinician works there.
NPPES lists 1 additional practice-address record in Fort Myers, FL. See the list
Source: CMS NPPES NPI Registry, practice location records; release date unavailable.
CMS Doctors and Clinicians lists 1 group name: Genesiscare Usa Of Florida Llc. See the list
Source: CMS Doctors and Clinicians National Downloadable File, release date unavailable.
Listings do not confirm current availability, employment or a shared ownership network.
Medicare Profile & Education
Source: CMS Doctors and Clinicians National Downloadable File
2015
What Public CMS Data Show
Physician Assistant: NPPES taxonomy is a reported classification, not proof of board certification.
Medicare patients
92 people with Original Medicare in 2024
It gives a sense of how many people with Medicare this clinician treated that year.
Source: CMS, Medicare Physician & Other Practitioners – by Provider, 2024.
Medicare-allowed amount
About $80,898 in 2024
The total amount Medicare approved for these services in 2024. It includes what Medicare paid and what patients or their other insurance owed, such as the deductible and coinsurance.
It shows the total cost of this clinician's Original Medicare services under Medicare's fee rules.
What this does not show: Medicare-allowed amount
This is not the clinician's income. Part of it can go to a clinic or group practice, staff, equipment or drugs. It is not the price you will pay.
Source: CMS, Medicare Physician & Other Practitioners – by Provider and Service, 2024.
Paid by Medicare
About $64,453 in 2024
The part of the Medicare-allowed amount that Medicare itself paid in 2024, after patients' deductibles and coinsurance.
The gap between the allowed amount and this number is roughly what patients and their other insurance paid.
What this does not show: Paid by Medicare
This is not the clinician's income and not a measure of quality.
Source: CMS, Medicare Physician & Other Practitioners – by Provider and Service, 2024.
30-day fills
303 standardized 30-day fills in 2024
CMS converts prescriptions to 30-day supplies so they can be compared. A 90-day prescription counts as about three 30-day fills.
What this does not show: 30-day fills
It is not a count of patients and not a measure of quality.
Part D drug cost
$16,592 in 2024
The total cost of these prescriptions in 2024, paid by Medicare drug plans, patients and other payers together.
It shows the total spending on drugs this clinician prescribed, not what any one patient paid.
What this does not show: Part D drug cost
A higher cost often reflects the type of medicines a specialty uses. It is not your out-of-pocket cost and not a measure of quality.
Source: CMS, Medicare Part D Prescribers – by Provider and Drug, 2024.
Open Payments general payments, program year 2025
All general payments: $78.40 across 3 records.
By nature of payment
- Food and Beverage: $78.40 across 3 records.
Reporting-company totals
- Novocure Inc.: $29.42 across 1 record.
- AstraZeneca Pharmaceuticals LP: $25.60 across 1 record.
- BIOPROTECT MEDICAL, INC.: $23.38 across 1 record.
A reported payment does not necessarily mean the financial relationship is improper and is not a measure of care quality. Clinicians can review and dispute these records.
Source: Calculated by T-MedInfo from CMS Open Payments general-payment records for program year 2025 (published June 30, 2026).
Years since graduation
11 years (graduated 2015)
CMS Doctors and Clinicians data list 2015 as the year this clinician finished professional school.
It tells you roughly how long ago the clinician finished school.
What this does not show: Years since graduation
It is not the number of years in practice, and more years does not mean better care.
Source: CMS Doctors and Clinicians National Downloadable File.
NPI first issued
2015
The year this clinician's National Provider Identifier (NPI) was issued. An NPI is a unique 10-digit ID that US health care providers use for billing.
What this does not show: NPI first issued
NPIs have been issued only since 2005, so this year is not necessarily when the clinician started practicing.
Source: CMS NPPES NPI Registry.
Accepts Medicare assignment
CMS data list this clinician as accepting Medicare assignment. This means agreeing to take the Medicare-approved amount as full payment for covered services.
With Original Medicare, you usually pay only your deductible and coinsurance, and the office sends the claim to Medicare for you.
Medicare assignment applies to Original Medicare. It does not tell you whether the clinician is in a Medicare Advantage plan's network, accepts other insurance, or is taking new patients.
Source: CMS Doctors and Clinicians; Medicare.gov, “Does your provider accept Medicare as full payment?”
No telehealth indicator
CMS shows this indicator only when recent Medicare claims include telehealth services. The clinician may still offer telehealth; ask the office.
Source: CMS, Telehealth Indicator on Medicare Care Compare (fact sheet, January 2023); CMS Doctors and Clinicians.
Enrolled in Medicare (PECOS)
Ryan Knake has a Medicare enrollment record in PECOS, the CMS system clinicians use to enroll so they can bill Medicare or order services for people with Medicare.
It does not show whether the clinician accepts assignment, is in your plan's network, or is taking new patients.
Source: CMS Medicare Fee-For-Service Public Provider Enrollment (PECOS); CMS Order and Referring file.
Can order Medicare-covered services
CMS lists Ryan Knake as eligible to order or refer Medicare Part B clinical laboratory and imaging services, durable medical equipment (DME) and home health services for people with Medicare.
Medicare pays for these items and services only when they are ordered by an eligible clinician.
What this does not show: Can order Medicare-covered services
It does not mean the clinician offers these services directly.
Source: CMS Medicare Fee-For-Service Public Provider Enrollment (PECOS); CMS Order and Referring file.
Compared with the same specialty in Cape Coral and Florida
Billing and prescribing volume is not a quality rating.
Medicare Part B services
More Medicare Part B services than 65% of clinicians listed under Physician Assistant in Cape Coral, FL (2024, 40 clinicians with data). Median for this group: 368. Middle half: 77 to 2,033.
More Medicare Part B services than 85% of clinicians listed under Physician Assistant in Florida (2024, 4,397 clinicians with data). Median for this group: 252. Middle half: 82 to 807.
Medicare-allowed amount
A higher Medicare-allowed amount than 70% of clinicians listed under Physician Assistant in Cape Coral, FL (2024, 40 clinicians with data). Median for this group: $26,506. Middle half: $7,734 to $83,588.
A higher Medicare-allowed amount than 80% of clinicians listed under Physician Assistant in Florida (2024, 4,397 clinicians with data). Median for this group: $19,984. Middle half: $7,371 to $51,670.
Paid by Medicare
A higher Medicare payment amount than 70% of clinicians listed under Physician Assistant in Cape Coral, FL (2024, 40 clinicians with data). Median for this group: $20,276. Middle half: $5,782 to $66,847.
A higher Medicare payment amount than 80% of clinicians listed under Physician Assistant in Florida (2024, 4,397 clinicians with data). Median for this group: $14,814. Middle half: $5,414 to $38,190.
Medicare Part D prescriptions
Close to the middle for clinicians listed under Physician Assistant in Cape Coral, FL (2024, 37 clinicians with data). Median for this group: 157. Middle half: 71 to 990.
Close to the middle for clinicians listed under Physician Assistant in Florida (2024, 4,894 clinicians with data). Median for this group: 270. Middle half: 78 to 825.
Part D drug cost
A higher Part D drug cost than 65% of clinicians listed under Physician Assistant in Cape Coral, FL (2024, 37 clinicians with data). Median for this group: $1,955. Middle half: $522 to $24,927.
A higher Part D drug cost than 60% of clinicians listed under Physician Assistant in Florida (2024, 4,894 clinicians with data). Median for this group: $5,225. Middle half: $703 to $70,250.
74 active clinicians are listed under Physician Assistant with a practice address in Cape Coral, FL (10,260 in Florida).
Addresses are self-reported to NPPES and may be out of date.
Telehealth indicator in Cape Coral
12.2% of these 74 clinicians have the CMS telehealth indicator.
59.5% of these 74 clinicians are listed by CMS as accepting Medicare assignment.
CMS data by year
Changes may reflect reporting, coverage or privacy limits, not changes in care quality.
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Medicare Part B services
Medicare Part B services increased 1083% from 142 in 2020 to 1,680 in 2024.
- 2020: 142
- 2021: 1,136
- 2022: 1,813
- 2023: 1,426
- 2024: 1,680
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Medicare-allowed amount
Medicare-allowed amount increased 784% from $9,155 in 2020 to $80,898 in 2024.
- 2020: $9,155
- 2021: $70,582
- 2022: $95,839
- 2023: $89,188
- 2024: $80,898
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Paid by Medicare
Paid by Medicare increased 804% from $7,127 in 2020 to $64,453 in 2024.
- 2020: $7,127
- 2021: $56,312
- 2022: $76,471
- 2023: $71,059
- 2024: $64,453
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Medicare Part D prescriptions
Medicare Part D prescriptions increased 66% from 127 in 2020 to 211 in 2024.
- 2020: 127
- 2021: 203
- 2022: 296
- 2023: 288
- 2024: 211
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30-day fills
30-day fills increased 89% from 161 in 2020 to 303 in 2024.
- 2020: 161
- 2021: 266
- 2022: 399
- 2023: 371
- 2024: 303
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Part D drug cost
Part D drug cost increased 366% from $3,559 in 2020 to $16,592 in 2024.
- 2020: $3,559
- 2021: $27,331
- 2022: $371,875
- 2023: $41,429
- 2024: $16,592
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Industry payments (Open Payments)
Industry payments (Open Payments) went from $228.19 in 2021 to $78.40 in 2025.
- 2021: $228.19
- 2022: $193.27
- 2023: $83.26
- 2024: $97.27
- 2025: $78.40
Sources: CMS Medicare Physician & Other Practitioners (2024), CMS Medicare Part D Prescribers (2024), CMS Open Payments (2025), CMS Doctors and Clinicians, CMS NPPES NPI Registry. Specialty names follow the NUCC Health Care Provider Taxonomy.
Text: T-MedInfo · Report an error.
Pharma & Medical Device Financial Disclosures
Payments and other transfers of value that drug and medical device companies reported to CMS Open Payments
Program year 2025 (payments made January 1 – December 31, 2025): fewer than 11 records totaling $78.40.
| Manufacturer | Payment Nature | Product | Type | Amount ($) |
|---|---|---|---|---|
| Novocure Inc. |
Food and Beverage
Cash or cash equivalent
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Optune Gio | General | $29.42 |
| AstraZeneca Pharmaceuticals LP |
Food and Beverage
In-kind items and services
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IMFINZI | General | $25.60 |
| BIOPROTECT MEDICAL, INC. |
Food and Beverage
In-kind items and services
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BIOPROTECT BALLOON IMPLANT SYSTEM | General | $23.38 |
Source: CMS Open Payments, program year 2025, released June 30, 2026.
Performed Procedures & Service Volume
CPT® is a registered trademark of the American Medical Association. CPT codes, descriptions and other data only are copyright 2017–2023 American Medical Association. All rights reserved. Applicable FARS/HHSARS apply. Descriptions of CPT codes are the AMA's CPT Consumer Friendly Descriptors as published by CMS in the Medicare Physician & Other Practitioners – by Provider and Service data, 2018–2024; they are plain-language summaries, not for clinical coding or documentation. HCPCS Level II codes and descriptions are from CMS. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein.
| HCPCS Code | Services | Patients | Submitted Charge | Medicare Allowed |
|---|---|---|---|---|
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99231
Subsequent hospital care with straightforward or low level of medical decision making, per day, if using time, at least 25 minutes
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1,296 | 77 | $127.69 | $41.62 |
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99232
Subsequent hospital care with moderate levelof medical decision making, if using time, at least 35 minutes
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307 | 33 | $226.52 | $65.26 |
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99222
Initial hospital care with straightforward or low-level medical decision making, if using time, at least 55 minutes
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39 | 39 | $443.10 | $109.15 |
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99221
Initial hospital care with straightforward or low level of medical decision making, per day, if using time, at least 40 minutes
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38 | 38 | $326.61 | $70.19 |
Source: CMS Part B by Provider and Service, 2024; services under 11 beneficiaries omitted by CMS. Privacy limits
Submitted charges are billed amounts, not a price quote for your visit.
Medicare Part D Prescribing Profile & Medications
Medicare Part D prescriptions filled, including refills, in 2024.
| Brand Name | Generic Name | Prescriptions | Day Supply | Total Cost | Patients |
|---|---|---|---|---|---|
| Tamsulosin Hcl | Tamsulosin Hcl | 57 | 3,723 | $517.91 | 29 |
| Prednisone | Prednisone | 36 | 1,111 | $254.18 | — |
| Abiraterone Acetate | Abiraterone Acetate | 29 | 1,110 | $13,890.94 | — |
| Bicalutamide | Bicalutamide | 20 | 900 | $466.75 | 14 |
| Oxycodone Hcl | Oxycodone Hcl | 18 | 108 | $109.90 | 15 |
| Mometasone Furoate | Mometasone Furoate | 17 | 496 | $651.70 | 15 |
| Ssd | Silver Sulfadiazine | 17 | 538 | $388.05 | 16 |
| Dexamethasone | Dexamethasone | 17 | 238 | $312.21 | — |
Source: CMS Part D by Provider and Drug, 2024; rows below 11 claims omitted by CMS; volume isn’t quality. Privacy limits
Specialties & License Numbers Reported to NPPES
NUCC Taxonomy Code: 363A00000X
A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and is practicing within the scope of that license. Physician assistants are formally trained to perform many of the routine, time-consuming tasks a physician can do. In some states, they may prescribe medications. They take medical histories, perform physical exams, order lab tests and x-rays, and give inoculations. Most states require that they work under the supervision of a physician.
Medicare (PECOS) Enrollment & Ordering Eligibility
Source: CMS PECOSPRACTITIONER - PHYSICIAN ASSISTANT
I20171208002255
FL
0244597730
Sources: CMS Provider Enrollment and Order and Referring. Medicare enrollment is a billing status, not an accreditation or quality rating.
Medicare Group Practice Enrollments
Source: CMS Doctors and Clinicians National Downloadable File
Genesiscare Usa Of Florida Llc
2721 Del Prado Blvd S, Cape Coral, FL 339045783
Genesiscare Usa Of Florida Llc
1419 Se 8th Ter, Cape Coral, FL 339903213
Phone: 2397723202
Genesiscare Usa Of Florida Llc
1680 S Central Blvd, Jupiter, FL 334587395
Phone: 5617482488
Genesiscare Usa Of Florida Llc
1419 Se 8th Ter, Cape Coral, FL 339903213
Secondary Practice Locations
7341 Gladiolus Dr
Fort Myers, FL 339085101
Phone: 2394893420
Clinicians Sharing This Practice Address or Phone
Clinicians sharing this NPPES address, phone or fax; a shared contact does not mean they work together.
Urology
Doctor of Medicine (M.D.)
Career & Practice History Timeline
Changes recorded in monthly NPPES data files: addresses, names, credentials, specialties and NPI status
NPI status registered as active in NPPES database
Registered at 2160 COLONIAL BLVD, FORT MYERS, FL 339071410 (Tel: 2399317342)
Registered at 7341 GLADIOLUS DR, FORT MYERS, FL 339085101 (Tel: 2394893420)
Recorded as RYAN KNAKE, PA-C
Physician Assistant (license number reported to NPPES: FL PA9108558)
NPI status registered as active in NPPES database
Registered at 7341 GLADIOLUS DR, FORT MYERS, FL 339085101 (Tel: 2394893420)
Registered at 2270 COLONIAL BLVD, FORT MYERS, FL 339071412 (Tel: 2399317333)
Recorded as RYAN KNAKE, PA-C
Physician Assistant (license number reported to NPPES: FL PA9108558)
First registered as active Individual Practitioner in NPPES Database.
NPI Administrative Meta
Other Physician Assistants in Cape Coral
- Kevin Poelker, PA
- Robert Paquin, PA
- Robert Enright, PA
- Nilda Toledo, PA-C
- Delicia Garner, PA-C
- Jonathan Hendricks, PA-C
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Mailing Address
2160 Colonial Blvd
Fort Myers, FL 339071410
Phone: 2399317342