Alyssa Marie Markee , ACNP-BC
Nurse Practitioner โข Houston, TX
1515 Holcombe Blvd
Houston, TX 770304000
This profile restates public CMS/NPPES data; T-MedInfo gives no medical advice — consult a licensed professional, and call 911 for emergencies.
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NPI assigned on April 5, 2011; this date does not establish years in practice.
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Published CMS data list 20 Original Medicare Part B services in 2023.
Source: CMS, Medicare Physician & Other Practitioners โ by Provider and Service, 2023. Published rows only; this is not a quality measure.
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Published Part B service records, 2023:
- 99214 โ Established patient outpatient office visit: 20 service units.
Source: CMS, Medicare Physician & Other Practitioners โ by Provider and Service, 2023. Units differ by code; these are not visits or a measure of quality.
CPTยฎ only copyright 2022 American Medical Association. All rights reserved. Service names are shortened from CPT Consumer Friendly Descriptors (CMS data, 2023). CPT notice
See the full table ยท Guide: How to read Medicare Part B data
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Published CMS data list 21 Medicare Part D prescriptions, including refills, in 2022.
Source: CMS, Medicare Part D Prescribers โ by Provider and Drug, 2022. Published rows only; this is not a quality measure.
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Published Part D records, 2022:
- Acyclovir โ 21 prescription fills, including refills.
Source: CMS, Medicare Part D Prescribers โ by Provider and Drug, 2022. Drug names come from pharmacy claims. Listing a drug here is not an endorsement or a recommendation.
See the full table ยท Guide: How to read Medicare Part D prescriber data
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Medicare Part B services went from 18 in 2019 to 20 in 2023.
Source: CMS, Medicare Physician & Other Practitioners โ by Provider and Service, 2019โ2023.
Practice Location & Contact Primary Location
1515 Holcombe Blvd
Houston, TX 770304000
Matched by practice address or phone in NPPES. A shared address or phone does not confirm that this clinician works there.
CMS Doctors and Clinicians lists 1 group name: Physicians Referral Service. See the list
Source: CMS Doctors and Clinicians National Downloadable File, release date unavailable.
Listings do not confirm current availability, employment or a shared ownership network.
Medicare Profile & Education
Source: CMS Doctors and Clinicians National Downloadable File
2009
What Public CMS Data Show
Nurse Practitioner: NPPES taxonomy is a reported classification, not proof of board certification.
Medicare-allowed amount
About $1,709 in 2023
The total amount Medicare approved for these services in 2023. It includes what Medicare paid and what patients or their other insurance owed, such as the deductible and coinsurance.
It shows the total cost of this clinician's Original Medicare services under Medicare's fee rules.
What this does not show: Medicare-allowed amount
This is not the clinician's income. Part of it can go to a clinic or group practice, staff, equipment or drugs. It is not the price you will pay.
Source: CMS, Medicare Physician & Other Practitioners โ by Provider and Service, 2023.
Paid by Medicare
About $1,368 in 2023
The part of the Medicare-allowed amount that Medicare itself paid in 2023, after patients' deductibles and coinsurance.
The gap between the allowed amount and this number is roughly what patients and their other insurance paid.
What this does not show: Paid by Medicare
This is not the clinician's income and not a measure of quality.
Source: CMS, Medicare Physician & Other Practitioners โ by Provider and Service, 2023.
30-day fills
25 standardized 30-day fills in 2022
CMS converts prescriptions to 30-day supplies so they can be compared. A 90-day prescription counts as about three 30-day fills.
What this does not show: 30-day fills
It is not a count of patients and not a measure of quality.
Part D drug cost
$664 in 2022
The total cost of these prescriptions in 2022, paid by Medicare drug plans, patients and other payers together.
It shows the total spending on drugs this clinician prescribed, not what any one patient paid.
What this does not show: Part D drug cost
A higher cost often reflects the type of medicines a specialty uses. It is not your out-of-pocket cost and not a measure of quality.
Source: CMS, Medicare Part D Prescribers โ by Provider and Drug, 2022.
Open Payments general payments, program year 2025
All general payments: $4,368.00 across 19 records.
By nature of payment
- Compensation for services other than consulting, including serving as faculty or as a speaker at a venue other than a continuing education program: $2,613.00 across 1 record.
- Food and Beverage: $924.51 across 14 records.
- Travel and Lodging: $830.49 across 4 records.
Reporting-company totals (3 largest of 5)
- Sanofi and Genzyme US Companies: $4,127.22 across 15 records.
- Sanofi and Genzyme US Companies: $122.69 across 1 record.
- JAZZ PHARMACEUTICALS INC.: $59.69 across 1 record.
A reported payment does not necessarily mean the financial relationship is improper and is not a measure of care quality. Clinicians can review and dispute these records.
Source: Calculated by T-MedInfo from CMS Open Payments general-payment records for program year 2025 (published June 30, 2026).
Years since graduation
17 years (graduated 2009)
CMS Doctors and Clinicians data list 2009 as the year this clinician finished professional school.
It tells you roughly how long ago the clinician finished school.
What this does not show: Years since graduation
It is not the number of years in practice, and more years does not mean better care.
Source: CMS Doctors and Clinicians National Downloadable File.
NPI first issued
2011
The year this clinician's National Provider Identifier (NPI) was issued. An NPI is a unique 10-digit ID that US health care providers use for billing.
What this does not show: NPI first issued
NPIs have been issued only since 2005, so this year is not necessarily when the clinician started practicing.
Source: CMS NPPES NPI Registry.
Accepts Medicare assignment
CMS data list this clinician as accepting Medicare assignment. This means agreeing to take the Medicare-approved amount as full payment for covered services.
With Original Medicare, you usually pay only your deductible and coinsurance, and the office sends the claim to Medicare for you.
Medicare assignment applies to Original Medicare. It does not tell you whether the clinician is in a Medicare Advantage plan's network, accepts other insurance, or is taking new patients.
Source: CMS Doctors and Clinicians; Medicare.gov, โDoes your provider accept Medicare as full payment?โ
No telehealth indicator
CMS shows this indicator only when recent Medicare claims include telehealth services. The clinician may still offer telehealth; ask the office.
Source: CMS, Telehealth Indicator on Medicare Care Compare (fact sheet, January 2023); CMS Doctors and Clinicians.
Enrolled in Medicare (PECOS)
Alyssa Markee has a Medicare enrollment record in PECOS, the CMS system clinicians use to enroll so they can bill Medicare or order services for people with Medicare.
It does not show whether the clinician accepts assignment, is in your plan's network, or is taking new patients.
Source: CMS Medicare Fee-For-Service Public Provider Enrollment (PECOS); CMS Order and Referring file.
Can order Medicare-covered services
CMS lists Alyssa Markee as eligible to order or refer Medicare Part B clinical laboratory and imaging services, durable medical equipment (DME) and home health services for people with Medicare.
Medicare pays for these items and services only when they are ordered by an eligible clinician.
What this does not show: Can order Medicare-covered services
It does not mean the clinician offers these services directly.
Source: CMS Medicare Fee-For-Service Public Provider Enrollment (PECOS); CMS Order and Referring file.
Compared with the same specialty in Houston and Texas
Billing and prescribing volume is not a quality rating.
Medicare Part B
Comparisons use 2024 data. The latest CMS data for Alyssa Markee are from 2023.
Medicare Part D
Comparisons use 2024 data. The latest CMS data for Alyssa Markee are from 2022.
785 active clinicians are listed under Nurse Practitioner with a practice address in Houston, TX (4,835 in Texas).
Addresses are self-reported to NPPES and may be out of date.
Telehealth indicator in Houston
13.6% of these 785 clinicians have the CMS telehealth indicator.
43.7% of these 785 clinicians are listed by CMS as accepting Medicare assignment.
CMS data by year
Changes may reflect reporting, coverage or privacy limits, not changes in care quality.
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Medicare Part B services
Medicare Part B services went from 18 in 2019 to 20 in 2023.
- 2019: 18
- 2020: 53
- 2023: 20
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Medicare-allowed amount
Medicare-allowed amount increased 24% from $1,375 in 2019 to $1,709 in 2023.
- 2019: $1,375
- 2020: $5,061
- 2023: $1,709
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Paid by Medicare
Paid by Medicare increased 24% from $1,099 in 2019 to $1,368 in 2023.
- 2019: $1,099
- 2020: $3,984
- 2023: $1,368
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Medicare Part D prescriptions
Medicare Part D prescriptions decreased 22% from 27 in 2019 to 21 in 2022.
- 2019: 27
- 2020: 28
- 2021: 47
- 2022: 21
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30-day fills
30-day fills decreased 17% from 30 in 2019 to 25 in 2022.
- 2019: 30
- 2020: 28
- 2021: 57
- 2022: 25
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Part D drug cost
Part D drug cost decreased 93% from $10,184 in 2019 to $664 in 2022.
- 2019: $10,184
- 2020: $240
- 2021: $1,429
- 2022: $664
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Industry payments (Open Payments)
Industry payments (Open Payments) went from $192.00 in 2023 to $4,368.00 in 2025.
- 2023: $192.00
- 2024: $72.22
- 2025: $4,368.00
Sources: CMS Medicare Physician & Other Practitioners (2023), CMS Medicare Part D Prescribers (2022), CMS Open Payments (2025), CMS Doctors and Clinicians, CMS NPPES NPI Registry. Specialty names follow the NUCC Health Care Provider Taxonomy.
Text: T-MedInfo ยท Report an error.
Pharma & Medical Device Financial Disclosures
Payments and other transfers of value that drug and medical device companies reported to CMS Open Payments
Program year 2025 (payments made January 1 โ December 31, 2025): 19 records totaling $4,368.00.
| Manufacturer | Payment Nature | Product | Type | Amount ($) |
|---|---|---|---|---|
| Sanofi and Genzyme US Companies |
Compensation for services other than consulting, including serving as faculty or as a speaker at a venue other than a continuing education program
Cash or cash equivalent
|
REZUROCK | General | $2,613.00 |
| Sanofi and Genzyme US Companies |
Travel and Lodging
In-kind items and services
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REZUROCK | General | $573.98 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
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REZUROCK | General | $152.16 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
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REZUROCK | General | $146.45 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
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REZUROCK | General | $146.42 |
| Sanofi and Genzyme US Companies |
Travel and Lodging
In-kind items and services
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REZUROCK | General | $137.74 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
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REZUROCK | General | $122.69 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
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REZUROCK | General | $120.89 |
| Sanofi and Genzyme US Companies |
Travel and Lodging
Cash or cash equivalent
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REZUROCK | General | $93.77 |
| JAZZ PHARMACEUTICALS INC. |
Food and Beverage
In-kind items and services
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DEFITELIO | General | $59.69 |
| Merck Sharp & Dohme LLC |
Food and Beverage
In-kind items and services
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PREVYMIS | General | $34.73 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
|
REZUROCK | General | $28.72 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
|
REZUROCK | General | $27.28 |
| Sanofi and Genzyme US Companies |
Travel and Lodging
Cash or cash equivalent
|
REZUROCK | General | $25.00 |
| Gamida Cell Inc. |
Food and Beverage
In-kind items and services
|
OMISIRGE | General | $23.67 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
|
REZUROCK | General | $20.41 |
| Sanofi and Genzyme US Companies |
Food and Beverage
Cash or cash equivalent
|
REZUROCK | General | $18.24 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
|
REZUROCK | General | $17.12 |
| Sanofi and Genzyme US Companies |
Food and Beverage
In-kind items and services
|
REZUROCK | General | $6.04 |
Source: CMS Open Payments, program year 2025, released June 30, 2026.
Performed Procedures & Service Volume
CPTยฎ is a registered trademark of the American Medical Association. CPT codes, descriptions and other data only are copyright 2018โ2022 American Medical Association. All rights reserved. Applicable FARS/HHSARS apply. Descriptions of CPT codes are the AMA's CPT Consumer Friendly Descriptors as published by CMS in the Medicare Physician & Other Practitioners โ by Provider and Service data, 2019โ2023; they are plain-language summaries, not for clinical coding or documentation. HCPCS Level II codes and descriptions are from CMS. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein.
| HCPCS Code | Services | Patients | Submitted Charge | Medicare Allowed |
|---|---|---|---|---|
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99214
Established patient office or other outpatient visit with moderate level of decision making, if using time, 30 minutes or more
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20 | 20 | $268.00 | $85.43 |
Source: CMS Part B by Provider and Service, 2023; services under 11 beneficiaries omitted by CMS. Privacy limits
Submitted charges are billed amounts, not a price quote for your visit.
Medicare Part D Prescribing Profile & Medications
Medicare Part D prescriptions filled, including refills, in 2022.
| Brand Name | Generic Name | Prescriptions | Day Supply | Total Cost | Patients |
|---|---|---|---|---|---|
| Acyclovir | Acyclovir | 21 | 750 | $664.38 | โ |
Source: CMS Part D by Provider and Drug, 2022; rows below 11 claims omitted by CMS; volume isn’t quality. Privacy limits
Specialties & License Numbers Reported to NPPES
Self-certified to NPPES: 2022-04-07NUCC Taxonomy Code: 363L00000X
(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision making and direct accountability for clinical judgment across the health care continuum or in a certified specialty. (2) A registered nurse who has completed additional training beyond basic nursing education and who provides primary health care services in accordance with state nurse practice laws or statutes. Tasks performed by nurse practitioners vary with practice requirements mandated by geographic, political, economic, and social factors. Nurse practitioner specialists include, but are not limited to, family nurse practitioners, gerontological nurse practitioners, pediatric nurse practitioners, obstetric-gynecologic nurse practitioners, and school nurse practitioners.
NUCC Taxonomy Code: 363L00000X
(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision making and direct accountability for clinical judgment across the health care continuum or in a certified specialty. (2) A registered nurse who has completed additional training beyond basic nursing education and who provides primary health care services in accordance with state nurse practice laws or statutes. Tasks performed by nurse practitioners vary with practice requirements mandated by geographic, political, economic, and social factors. Nurse practitioner specialists include, but are not limited to, family nurse practitioners, gerontological nurse practitioners, pediatric nurse practitioners, obstetric-gynecologic nurse practitioners, and school nurse practitioners.
NUCC Taxonomy Code: 363L00000X
(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision making and direct accountability for clinical judgment across the health care continuum or in a certified specialty. (2) A registered nurse who has completed additional training beyond basic nursing education and who provides primary health care services in accordance with state nurse practice laws or statutes. Tasks performed by nurse practitioners vary with practice requirements mandated by geographic, political, economic, and social factors. Nurse practitioner specialists include, but are not limited to, family nurse practitioners, gerontological nurse practitioners, pediatric nurse practitioners, obstetric-gynecologic nurse practitioners, and school nurse practitioners.
NUCC Taxonomy Code: 363LA2100X
Additional State Medicaid & Healthcare Payer Identifiers
Medicare (PECOS) Enrollment & Ordering Eligibility
Source: CMS PECOSPRACTITIONER - NURSE PRACTITIONER
I20110627000731
TX
3375721103
Sources: CMS Provider Enrollment and Order and Referring. Medicare enrollment is a billing status, not an accreditation or quality rating.
Medicare Group Practice Enrollments
Source: CMS Doctors and Clinicians National Downloadable File
Physicians Referral Service
1515 Holcombe Blvd, Houston, TX 770304000
Phone: 7137922121
Clinicians Sharing This Practice Address or Phone
Clinicians sharing this NPPES address, phone or fax; a shared contact does not mean they work together.
Psychologist - Clinical
Doctor of Philosophy (Ph.D.)
Internal Medicine - Hematology
Doctor of Medicine (M.D.), Doctor of Philosophy (Ph.D.)
Anesthesiology
Doctor of Osteopathic Medicine (D.O.)
Internal Medicine - Gastroenterology
Doctor of Medicine (M.D.)
Nurse Practitioner - Acute Care
Master of Science in Nursing, Advanced Practice Registered Nurse, ACNPCAG
Internal Medicine
Doctor of Medicine (M.D.)
Career & Practice History Timeline
Changes recorded in monthly NPPES data files: addresses, names, credentials, specialties and NPI status
Registered at 1515 HOLCOMBE BLVD, HOUSTON, TX 770304000 (Tel: 7137926161)
Registered at PO BOX 4439, HOUSTON, TX 772104439 (Tel: 7137922991)
Recorded as ALYSSA MARKEE, ACNP-BC
Registered at 300 PASTEUR DR, STANFORD, CA 943052200 (Tel: 6507234000)
Registered at 300 PASTEUR DR, STANFORD, CA 943052200 (Tel: 6507234000)
NPI status registered as active in NPPES database
Registered at 825 EASTLAKE AVE E STE 100, SEATTLE, WA 981094405 (Tel: 2065436420)
Registered at PO BOX 50095, SEATTLE, WA 981455095 (Tel: (206) 543-6420)
Recorded as ALYSSA TWIGG, ACNP-BC
Nurse Practitioner (license number reported to NPPES: WA AP60750906)
Registered at 825 EASTLAKE AVE E STE 100, SEATTLE, WA 981094405 (Tel: 2065436420)
Registered at PO BOX 50095, SEATTLE, WA 981455095 (Tel: (206) 543-6420)
Nurse Practitioner (license number reported to NPPES: WA AP60750906)
NPI status registered as active in NPPES database
Registered at 4101 JAMES CASEY ST, STE 100, AUSTIN, TX 787453325 (Tel: 5124472202)
Registered at PO BOX 911230, DALLAS, TX 753911230 (Tel: 9729978000)
Recorded as ALYSSA TWIGG, ACNP-BC
Nurse Practitioner (license number reported to NPPES: TX 782580)
First registered as active Individual Practitioner in NPPES Database.
NPI Administrative Meta
Other Nurse Practitioners in Houston
- Tonya Edwards, APRN
- Ellen Mullen, RN, ANP, GNP
- Dharusal Patel, MSN, APRN, FNP-C, PCCN
- Peter Amokeodo, NP-C
- Dayana Garza, NP-C
- Kimberly Diel, AGACNP-BC
Mailing Address
Po Box 4439
Houston, TX 772104439
Phone: 7137922991